THE EFFECT OF AGMATINE ON SPIKE-AND-WAVE DISCHARGES IN A GENETIC MODEL OF ABSENCE EPILEPSY

Objective: Studies on the actions of exogenous agmatine in experimental models have shown its anti-convulsant effects. However, there are no findings regarding influence absence epilepsy. Therefore, we investigated effects occurrence spike-and-wave discharges (SWDs) Wistar Albino Glaxo Rijswijk rats (WAG/Rij) model genetic Material and Method: Three different doses (20, 40 or 80 mg/ kg) saline were administered intraperitoneally to adult WAG/Rij rats, electroencephalography (EEG) was recorded for 2.5 hours. The number mean cumulative durations SWDs measured. SWD frequency characteristics quantified by means average power-spectra first 2 s segments complexes before after effective dose agmatine. Results: Agmatine, mg/kg systemically, temporarily increased duration compared with injected rats. This effect agmatine, however, not associated any change complexes. There neither incidence nor when lower (20 mg/kg). Conclusion: Higher slightly increase which may suggest possible aggravating activity epilepsy patients through adrenergic, serotonergic AMPA receptors.